Cytokeratin 10 Antibody MBS438158 from MyBioSource.com

Product Specs
ItemCytokeratin 10 Antibody
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS438158
Quantity0.1 mg
ApplicationsELISA (EIA),Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
Conjugate/TagUnconjugated
ReactivityHuman, Mouse
TargetCytokeratin 10
IsotypeIgG1
Molecular Weight56.5kDa
CloneSPM261
HostMouse
ImmunogenThis MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts
NCBI Full Gene Namekeratin 10, type I
NCBI Gene AliasesKPP, K10, BIE, CK10, BCIE, EHK
ClonalityMonoclonal